DEVELOPMENT OF A SENSOR BY ELECTRO-POLYMERIZATION O F ERICHROME BLACK-T ON GLASSY CARBON ELECTRODE AND DETERMINATION OF AN ANT I-INFLAMMATORY DRUG DICLOFENAC
By: Hanabaratti, Rohini M
.
Contributor(s): Gowda, Jayant I.
Publisher: M P Innovare Academic Sciences Pvt Ltd 2019Edition: Vol.11(2).Description: 81-87p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
International journal of pharmacy and pharmaceutical scienceSummary: Objective:
The aim of this study was to develop a simple, reli
able voltammetric method and its validation for det
ermination of nonsteroidal anti-
inflammatory drug diclofenac (DFC).
Methods:
The proposed method was based on electro-oxidation
of DFC at poly (erichrome black T) modified glassy
carbon electrode (PEBT/GCE)
in 0.2 M phosphate buffer solution of pH 7.0. Cyclic
voltammetry and differential pulse voltammetric te
chniques were employed to study electro-
oxidation behavior. Under the optimal conditions, v
ariations of EBT concentration, effect of pH, scan r
ate on the oxidation of DFC was studied.
Results:
A well-defined oxidation peak at about +0.59 V vs.
standard calomel electrode was observed for voltamm
etric detection of DFC. pH effect
shows the participation of an equal number of proto
ns and electrons in the mechanism. The relation bet
ween a logarithm of peak current with the
logarithm of scan rate indicated adsorption control
led behavior of electrode process. Concentration va
riations show a good linear response in the
range 0.05 μM to 40 μM with the detection limit of
5.25 × 10
-8
M.
Conclusion
:
The prepared sensor exhibited good selectivity, sen
sitivity, and stability for the detection of DFC in
the pharmaceutical dosage form
and real samples. The developed method could possib
ly be adopted for pharmacokinetic studies and also
in clinical and quality control laboratories
where time and economy were important.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2020892 |
Objective:
The aim of this study was to develop a simple, reli
able voltammetric method and its validation for det
ermination of nonsteroidal anti-
inflammatory drug diclofenac (DFC).
Methods:
The proposed method was based on electro-oxidation
of DFC at poly (erichrome black T) modified glassy
carbon electrode (PEBT/GCE)
in 0.2 M phosphate buffer solution of pH 7.0. Cyclic
voltammetry and differential pulse voltammetric te
chniques were employed to study electro-
oxidation behavior. Under the optimal conditions, v
ariations of EBT concentration, effect of pH, scan r
ate on the oxidation of DFC was studied.
Results:
A well-defined oxidation peak at about +0.59 V vs.
standard calomel electrode was observed for voltamm
etric detection of DFC. pH effect
shows the participation of an equal number of proto
ns and electrons in the mechanism. The relation bet
ween a logarithm of peak current with the
logarithm of scan rate indicated adsorption control
led behavior of electrode process. Concentration va
riations show a good linear response in the
range 0.05 μM to 40 μM with the detection limit of
5.25 × 10
-8
M.
Conclusion
:
The prepared sensor exhibited good selectivity, sen
sitivity, and stability for the detection of DFC in
the pharmaceutical dosage form
and real samples. The developed method could possib
ly be adopted for pharmacokinetic studies and also
in clinical and quality control laboratories
where time and economy were important.
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